A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called histone deacetylase inhibitors.
A synthetic derivative of hydroxamic acid with antineoplastic properties, Pyroxamide inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin structure and affecting transcription of some genes that inhibit tumor growth; and induces growth arrest and apoptosis. Pyroxamide is used in clinical studies for cancer chemotherapy.
Pyroxamide has been defined 3 different ways in documents like Glossary of Cancer Terms, NCI Drug Dictionary, NCI Dictionary of Cancer Terms.