Satellite-based ozone-measuring instruments can measure ozone by looking at the amount of ultraviolet absorption reflected from the Earth's surface and clouds. Some instruments provide data within the different levels of the atmosphere. The Total Ozone Mapping Spectrometer (TOMS) maps the total amount of ozone between ground and the top of the atmosphere.

The amount and distribution of ozone molecules in the stratosphere varies greatly over the globe, changing in response to natural cycles such as seasons, sun cycles, and winds. Utilizing satellites has enabled scientists to assess ozone levels simultaneously over the entire Earth, and has led them to conclude that global ozone levels are being depleted.

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