A drug used to treat Ewing sarcoma, gestational trophoblastic tumor, Wilms tumor, and certain types of testicular cancer. It is also used to treat rhabdomyosarcoma in children. It is being studied in the treatment of other types of cancer. Dactinomycin comes from the bacterium Streptomyces parvulus. It damages the cell’s DNA and may kill cancer cells. It is a type of anticancer antibiotic.
A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II.