D-Cycloserine
3 definitions

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A drug used to treat tuberculosis. It is also being studied in the treatment of pain and nerve problems (numbness, tingling) caused by chemotherapy and in the treatment of low back pain, autism, certain anxiety disorders, and schizophrenia. D-cycloserine is a type of antibiotic.

FK Reading Ease
39.3

FK Grade Level
High School
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  • This definition has not yet been approved by a moderator.

    An analogue of the amino acid D-alanine with broad-spectrum antibiotic and glycinergic activities. D-cycloserine interferes with bacterial cell wall synthesis by competitively inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby impairing peptidoglycan formation necessary for bacterial cell wall synthesis. This agent may be bactericidal or bacteriostatic, depending on its concentration at the infection site and the susceptibility of the organism. In addition, D-cycloserine is an excitatory amino acid and partial agonist at the glycine binding site of the NMDA receptor in the central nervous system (CNS); binding to the central NMDA receptor may result in amelioration of neuropathic pain.

    FK Reading Ease
    -1.5

    FK Grade Level
    Graduate School
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  • A drug used to treat tuberculosis. It is also being studied in the treatment of pain and nerve problems (numbness, tingling) caused by chemotherapy and in the treatment of low back pain, autism, certain anxiety disorders and schizophrenia. D-cycloserine belongs to the family of drugs called antibiotics. Also called Seromycin.

    FK Reading Ease
    38

    FK Grade Level
    High School
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