A substance being studied in the treatment of cancer. It is a type of radiosensitizer.
A radio-sensitizing pyrimidine nucleoside with potential antineoplastic activity. Cytochlor is metabolized first to a phosphate derivative, CldCMP, by the enzyme deoxycytidine kinase and then to the active uracyl derivative, CldUMP, by the enzyme dCMP deaminase; deoxycytidine kinase and dCMP deaminase have been found in abnormally high concentrations in most cancers. CldUMP, the active metabolite, incorporates into DNA and, upon exposure to radiation, induces the formation of uracil radicals and double-strand DNA breaks.
A substance being studied in the treatment of cancer that has spread to the brain. It has also been studied in the treatment of other types of cancer. Cytochlor damages the DNA in cancer cells, which may make them easier to kill with radiation therapy. It is a type of radiosensitizing agent.
Cytochlor has been defined 3 different ways in documents like Glossary of Cancer Terms, NCI Drug Dictionary, NCI Dictionary of Cancer Terms.