C-Met Inhibitor AMG 208
1 definition

C-Met Inhibitor AMG 208

A selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 208 inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity, which may result in cell growth inhibition in tumors that overexpress c-Met. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase, plays an important role in epithelial cell proliferation and has been shown to be overexpressed in a variety of cancers.

Loading conversations.
About this term

Add more variations to this definition by clicking on Add a definition button above.

Similar or Related Terms