A substance being studied in the treatment of cancer. It is a type of antitubulin agent. Also called benzoylphenylurea.
A low molecular weight agent with antineoplastic activity. Benzoylphenylurea binds to the colchicine binding site on tubulin, thereby blocking tubulin polymerization and disrupting mitotic function. This agent also inhibits DNA polymerase, and has been shown to arrest leukemia cells in the G1-S transition phase of the cell cycle.
Benzoylphenylurea has been defined 3 different ways in documents like Glossary of Cancer Terms, NCI Drug Dictionary, NCI Dictionary of Cancer Terms.