B43-PAP Immunotoxin
3 definitions

This definition has not yet been approved by a moderator.

A toxic substance linked to an antibody that attaches to tumor cells and kills them.

FK Reading Ease
67.5

FK Grade Level
Middle School
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  • This definition has not yet been approved by a moderator.

    A mouse-derived anti-human CD19 monoclonal antibody linked to pokeweed (Phytolacca americana) antiviral protein (PAP) with antileukemic activity. The monoclonal antibody portion specifically binds to the CD19 antigen, a cell surface molecule normally expressed only by B lymphocytes and follicular dendritic cells and over-expressed in B-lineage lymphocytic leukemia cells. Following internalization, PAP, a plant hemitoxin and a ribosome-inactivating protein, is cleaved from the immunoconjugate and released into the cytoplasm where it enzymatically removes a single adenine base from a conserved, surface exposed loop sequence of rRNA leading to inhibition of protein synthesis and cell growth, but not necessarily cell death.

    FK Reading Ease
    -7.3

    FK Grade Level
    Graduate School
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  • A toxic substance linked to an antibody that attaches to tumor cells and kills them.

    FK Reading Ease
    67.5

    FK Grade Level
    Middle School
  • Flag